|B cell control mechanisms|
Inhibitors of TNF superfamily proteins have also been tested in the clinic, with some becoming successful approved treatments, highlighting the potential for research in this area to lead to new treatments.
Reference: Figgett WA, et al. Roles of ligands from the TNF superfamily in B cell development, function, and regulation. Seminars in Immunology (2014), http://dx.doi.org/10.1016/j.
Brain fog. Image:
|Prof Frank Rosenfeldt|
with the ex vivo rig
Despite increasing use of donation after cardiac death (DCD) and encouraging results for non-cardiac transplants, DCD cardiac transplantation has not been widely adopted for two reasons. The DCD heart sustains warm ischaemic injury during the death process and conventional static cold storage significantly adds to the ischaemic injury. Alfred-Monash researchers have developed a simple system for perfusion of the DCD heart with cold crystalloid solution using gravity-feed that can reduce ischaemic injury and potentially render the heart suitable for transplantation.