Prof Gary Maartens, Prof Connie Celum and Prof Sharon Lewin, Department of Infectious Diseases, have published a seminar article in The Lancet, "HIV infection:
epidemiology, pathogenesis, treatment, and prevention". Sharon gives an overview of the article, including her own area of pathogenesis, covering recent developments in immune activation and vaccine development. "No-one clears HIV spontaneously", she says, which is a very unusual feature for a virus. Treatments are now investigating latency, or how to 'wake up' dormant virus hidden within cells. #HIV also causes low level inflammation from immune activation, which contributes to chronic disease development. See The Lancet abstract.